1. Making TwoXChromosomes a Default Subreddit Has Not Gone Over Well ...
20 mei 2014 · As of a few weeks ago, TwoXChromosomes became a default subreddit, meaning it is one of the subreddits new users are autmatically subscribed to.
Yesterday, I ran a Q&A I did with the founder of the woman-focused subreddit TwoXChromosomes. As of a few weeks ago, TwoXChromosomes became a default subreddit, meaning it is one of t...
2. As a woman who finally gave up on twoxchromosomes because I felt is ...
3 jan 2023 · As a woman who finally gave up on twoxchromosomes because I felt is was a bit too toxic I somewhat disagree on it not being toxic.
sonjat on Jan 3, 2023 | parent | context | favorite | on: Men Without Work (2016)
3. X Chromosome Inactivation | Learn Science at Scitable - Nature
However, females carry two copies of the X chromosome, resulting in a potentially toxic double dose of X-linked genes. To correct this imbalance, mammalian ...
The sex chromosomes raise an interesting dilemma: females (XX) carry twice as many X-linked genes as males (XY), and this double dose is lethal to the early embryo. So how does nature resolve this problem? In mammals, females transcriptionally “shut off” one of their two X chromosomes to equalize X-linked gene dosage between the sexes. This process is called X inactivation, and it exists in two varieties: random and imprinted.
4. The Chromosomal Cause of the Calico-Colored Cat
However, females carry two copies of the X-chromosome, resulting in a potentially toxic double dose of X-linked genes. To correct this disparity, mammalian ...
Have you ever been told that almost all calico-coloured cats are female? Have you ever wondered how such a thing could be true? The answer to this lies within their DNA; with a phenomenon found in all female mammals called X-chromosome inactivation. The sex-determining system of all mammals dictates that...
5. Xist - NIH Director's Blog
15 feb 2024 · Xist molecules shut down one of two female X chromosomes to avoid toxic protein levels, but they may also play a role in triggering ...
Posted on February 15th, 2024 by Dr. Monica M. Bertagnolli
6. Why women are at higher risk for autoimmune disorders
29 apr 2024 · That second X chromosome is the reason women are more susceptible than men to autoimmune disorders, according to a study published Feb.
A molecule made by one X chromosome in every female cell can generate antibodies to a woman’s own tissues.
7. Ornithine Transcarbamylase Deficiency
Ammonia is a normal waste product formed when the body breaks down proteins, however it becomes toxic ... Girls have two X chromosomes and so even if one ...
Ornithine transcarbamylase deficiency, commonly called OTC deficiency, is a rare genetic condition that causes ammonia to build up in the blood.
8. Female genetic superiority: when it comes to survival, two X ... - CBC
19 jun 2020 · ... two X chromosomes beat an X and a Y ... The other differences In mortality are due to the consequences of men being the ones who work in toxic ...
In his new book ‘Better Half’, Dr. Sharon Moalem explains the survival advantage that allows women to better overcome biological challenges throughout their lives than men.
9. Clonal Origin of Toxic Thyroid Nodules with Constitutively ...
... two X-chromosomes occurs in all female somatic cells in early embryogenesis. Functional inactivation is accomplished by DNA methylation at CpG sites. The ...
Constitutively activating TSH receptor mutations have recently been detected in toxic nodules. In vitro studies suggest that mutated receptor signaling con
10. Why Do Women Have More Autoimmune Diseases? Study ...
1 feb 2024 · That's because one of the two X chromosomes is silenced. A ... toxic. In 2015, it occurred to Dr. Chang that the silencing itself ...
The molecules that silence a woman’s second X chromosome can confuse the immune system, a new study suggests.
11. X Chromosome Linked to Autoimmune Diseases - VOA
3 feb 2024 · One theory is that the X chromosome might be a culprit. After all, females have two X chromosomes while males have one X and one Y. The new ...
Research sheds light on why women are more prone to lupus, multiple sclerosis and other autoimmune diseases
12. MeCP2-boosting Approaches May Lead to Toxic Events in Mild Rett
28 mei 2021 · ... two X chromosomes (one from each biological parent) and that randomly “turns off” one of the chromosomes in each cell. While previous ...
Providing a working version of the MECP2 gene to cells reversed almost all disease-specific symptoms in a Rett mouse model. But there are concerns.
13. Investigating toxicity changes of cross-community redditors from 2 ...
18 aug 2022 · r/TwoXChromosomes, 11,215,698, 52,283, 3,002,720. 48, r/Fitness, 6,186,196, 115,007, 4,672,605. 49, r/technology, 5,551,587, 267,264, 9,225,651.
This research investigates changes in online behavior of users who publish in multiple communities on Reddit by measuring their toxicity at two levels. With the aid of crowdsourcing, we built a labeled dataset of 10,083 Reddit comments, then used the dataset to train and fine-tune a Bidirectional Encoder Representations from Transformers (BERT) neural network model. The model predicted the toxicity levels of 87,376,912 posts from 577,835 users and 2,205,581,786 comments from 890,913 users on Reddit over 16 years, from 2005 to 2020. This study utilized the toxicity levels of user content to identify toxicity changes by the user within the same community, across multiple communities, and over time. As for the toxicity detection performance, the BERT model achieved a 91.27% classification accuracy and an area under the receiver operating characteristic curve (AUC) score of 0.963 and outperformed several baseline machine learning and neural network models. The user behavior toxicity analysis showed that 16.11% of users publish toxic posts, and 13.28% of users publish toxic comments. However, results showed that 30.68% of users publishing posts and 81.67% of users publishing comments exhibit changes in their toxicity across different communities, indicating that users adapt their behavior to the communities’ norms. Furthermore, time series analysis with the Granger causality test of the volume of links and toxicity in user content showed that toxic comments are Granger caused by l...
