Article Oncology
Longitudinal associations of plasma metabolites with persistent fatigue among colorectal cancer survivors up to 2 years after treatment
Eline H. van Roekel, Martijn J. L. Bours, Stephanie O. Breukink, Michel Aquarius, Eric T. P. Keulen, Audrey Gicquiau, Sabina Rinaldi, Paolo Vineis, Ilja C. W. Arts, Marc J. Gunter, Michael F. Leitzmann, Augustin Scalbert, Matty P. Weijenberg
Summary: Further investigation is needed to understand the biological mechanisms causing persistent fatigue after colorectal cancer treatment. This study found longitudinal associations between various metabolites and fatigue in colorectal cancer survivors, suggesting inflammation and mitochondrial dysfunction as underlying mechanisms. These findings contribute to a better understanding of persistent fatigue after colorectal cancer treatment.
INTERNATIONAL JOURNAL OF CANCER (2023)
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Article Oncology
Longitudinal associations of sedentary behavior and physical activity with body composition in colorectal cancer survivors up to 2 years post treatment
Marlou-Floor Kenkhuis, Mo Klingestijn, Anne-Marie Fanshawe, Stephanie O. Breukink, Maryska L. G. Janssen-Heijnen, Eric T. P. Keulen, Sabina Rinaldi, Paolo Vineis, Marc J. Gunter, Michael F. Leitzmann, Augustin Scalbert, Matty P. Weijenberg, Martijn J. L. Bours, Eline H. van Roekel
Summary: This study examined the longitudinal associations of sedentary behavior, light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with body composition in colorectal cancer survivors. The results showed that less sedentary time and LPA were associated with increased handgrip strength, independent of MVPA. However, they were not associated with measures of adiposity. On the other hand, more MVPA was associated with increased adiposity and handgrip strength. Additionally, higher BMI partly mediated the associations between higher sedentary time and more fatigue.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)
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Article Oncology
Longitudinal associations of sociodemographic, lifestyle, and clinical factors with alcohol consumption in colorectal cancer survivors up to 2 years post-diagnosis
Dora Revesz, Martijn J. L. Bours, Johannes A. Wegdam, Eric T. P. Keulen, Stephanie O. Breukink, Gerrit D. Slooter, F. Jeroen Vogelaar, Matty P. Weijenberg, Floortje Mols
Summary: Colorectal cancer survivors reduced their alcohol consumption in the 2 years post-diagnosis. Factors associated with higher alcohol consumption post-diagnosis include being male, having higher education, engaging in more physical activity, and not having a stoma.
SUPPORTIVE CARE IN CANCER (2021)
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Article Sport Sciences
Longitudinal Associations of Sedentary Behavior and Physical Activity with Quality of Life in Colorectal Cancer Survivors
Marlou Floor Kenkhuis, Eline H. Van Roekel, Jose J. L. Breedveld-Peters, Stephanie O. Breukink, Maryska L. G. Janssen-Heijnen, Eric T. P. Keulen, Franzel J. B. Van Duijnhoven, Floortje Mols, Matty P. Weijenberg, Martijn J. L. Bours
Summary: The study found that reducing sedentary behavior and increasing moderate to vigorous physical activity are beneficial for the HRQoL and fatigue levels of CRC survivors. However, no associations were found for CIPN complaints. Furthermore, a synergistic interaction was observed between prolonged sedentary behavior and moderate to vigorous physical activity in affecting functioning scales.
Article Oncology
Longitudinal Associations between Inflammatory Markers and Fatigue up to Two Years after Colorectal Cancer Treatment
Nadira R. Querido, Marlou-Floor Kenkhuis, Eline H. van Roekel, Stephanie O. Breukink, Franzel J. B. van Duijnhoven, Maryska L. G. Janssen-Heijnen, Eric T. P. Keulen, Per Magne Ueland, F. Jeroen Vogelaar, Evertine Wesselink, Martijn J. L. Bours, Matty P. Weijenberg
Summary: Long-term inflammation is associated with posttreatment fatigue in colorectal cancer survivors.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2022)
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Article Oncology
Plasma Metabolomics and Breast Cancer Risk over 20 Years of Follow-up among Postmenopausal Women in the Nurses' Health Study
Kristen D. Brantley, Oana A. Zeleznik, Bernard Rosner, Rulla M. Tamimi, Julian Avila-Pacheco, Clary B. Clish, A. Heather Eliassen
Summary: This study explored the association between metabolites and breast cancer risk and found that cholesteryl esters measured earlier in disease etiology were inversely associated with breast cancer, while triacylglycerols with many double bonds measured closer to diagnosis were inversely associated with breast cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2022)
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Article Geriatrics & Gerontology
Cross-Sectional and Longitudinal Associations Between Plasma Neurodegenerative Biomarkers and Physical Performance Among Community-Dwelling Older Adults
Lingxiao He, Philipe de Souto Barreto, Kelly Giudici, Geetika Aggarwal, Andrew D. Nguyen, John E. Morley, Yan Li, Randall J. Bateman, Bruno Vellas
Summary: This study aimed to explore the relationship between plasma Aβ, NfL, and PGRN levels and physical performance in older adults. The results showed that higher plasma NfL levels were associated with lower physical performance scores, while higher PGRN levels were linked to decreasing handgrip strength over time.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)
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Article Oncology
Longitudinal Associations of Former and Current Alcohol Consumption with Psychosocial Outcomes among Colorectal Cancer Survivors 1-15 Years after Diagnosis
Dora Revesz, Martijn J. L. Bours, Matty P. Weijenberg, Floortje Mols
Summary: This study aimed to explore the association between alcohol consumption and psychosocial outcomes among colorectal cancer survivors. The results showed that current drinking was associated with less anxiety, depression, and better health-related quality of life (HRQoL), whereas former drinking was associated with worse psychosocial outcomes. Moderate and heavy alcohol consumption, especially wine, were associated with less anxiety, depression, and better HRQoL. More drinks per week were associated with less nausea/vomiting.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2022)
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Article Multidisciplinary Sciences
A longitudinal study of physical activity among Malaysian breast cancer survivors
Yi Lin Lee, Tania Islam, Mahmoud Danaee, Nur Aishah Taib
Summary: Regular physical activity after breast cancer diagnosis is associated with reduced mortality and better quality of life. However, this study found that breast cancer survivors in Malaysia had inadequate physical activity levels at diagnosis, which decreased over time. Malay ethnicity and being underweight were significantly associated with low physical activity levels. It is important to communicate about the benefits of physical activity on cancer outcomes and continue to encourage breast cancer survivors to be physically active throughout their survivorship, particularly among Malay ethnic group and underweight patients.
PLOS ONE (2022)
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Article Nutrition & Dietetics
Longitudinal associations of fiber, vegetable, and fruit intake with quality of life and fatigue in colorectal cancer survivors up to 24 months posttreatment
Marlou-Floor Kenkhuis, Franzel J. B. van Duijnhoven, Eline H. van Roekel, Jose J. L. Breedveld-Peters, Stephanie O. Breukink, Maryska L. Janssen-Heijnen, Eric T. P. Keulen, Floortje Mols, Matty P. Weijenberg, Martijn J. L. Bours
Summary: The study found that increasing dietary fiber, fruit, and vegetable intake is associated with better physical functioning and less fatigue in colorectal cancer survivors in the first two years after treatment.
AMERICAN JOURNAL OF CLINICAL NUTRITION (2022)
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Article Oncology
The Association between Sleep Quality and Fatigue in Colorectal Cancer Survivors up until Two Years after Treatment: A Cross-Sectional and Longitudinal Analysis
Meera Legg, Ree M. Meertens, Eline van Roekel, Stephanie O. Breukink, Maryska L. Janssen, Eric T. P. Keulen, Karen Steindorf, Matty P. Weijenberg, Martijn Bours
Summary: This study aimed to investigate the association between sleep quality and fatigue in colorectal cancer survivors. The results showed that worse sleep quality in colorectal cancer patients was associated with higher levels of fatigue during the first two years post-treatment. Therefore, attention should be paid to sleep quality and sleep health interventions may help reduce fatigue and improve quality of life in colorectal cancer survivors.
CANCERS (2022)
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Article Oncology
Physical activity and sedentary time: associations with fatigue, pain, and depressive symptoms over 4 years post-treatment among breast cancer survivors
Isabelle Dore, Audrey Plante, Serena S. Peck, Nathalie Bedrossian, Catherine M. Sabiston
Summary: This study investigated how moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) predict depressive symptoms, pain, and fatigue in breast cancer survivors over a 4-year period post-treatment. The results showed that higher levels of MVPA were associated with lower depressive symptoms, while higher levels of ST were linked to higher depressive symptoms and increased pain levels over time. In conclusion, rehabilitation interventions for breast cancer survivors should focus on increasing MVPA and reducing ST to improve overall health and well-being, especially during the early post-treatment period.
SUPPORTIVE CARE IN CANCER (2022)
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Article Oncology
Physical activity levels among ovarian cancer survivors: a prospective longitudinal cohort study
Tamara Jones, Carolina Sandler, Dimitrios Vagenas, Monika Janda, Andreas Obermair, Sandra Hayes
Summary: Physical activity following ovarian cancer diagnosis is generally below recommended levels, with some patients experiencing a decrease in activity levels. Patients with advanced stage disease, lower income, undergoing chemotherapy, currently smoking, or working are more likely to report lower physical activity levels and have increased odds of being insufficiently active or sedentary.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2021)
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Article Oncology
Longitudinal associations among physical activity and sitting with endocrine symptoms and quality of life in breast cancer survivors: A latent growth curve analysis
Alexander R. Lucas, Youngdeok Kim, Autumn Lanoye, R. Lee Franco, Arnethea L. Sutton, Jessica G. Larose, Masey Ross, Vanessa B. Sheppard
Summary: This study found that both increasing physical activity and reducing prolonged sitting are important for managing symptoms and maintaining quality of life in breast cancer survivors undergoing adjuvant endocrine therapy. Higher levels of physical activity were associated with better quality of life, while increased sitting time was associated with worse symptoms and quality of life.
CANCER MEDICINE (2023)
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Article Oncology
Association of physical activity with overall mortality among long-term testicular cancer survivors: A longitudinal study
Lene Thorsen, Kerry S. S. Courneya, Jostein Steene-Johannessen, Jon Michael Gran, Hege S. S. Haugnes, Helene F. S. Negaard, Cecilie E. E. Kiserud, Sophie D. D. Fossa
Summary: Physical activity during survivorship is associated with reduced overall mortality among testicular cancer survivors, especially for those who engage in regular and persistent exercise. Long-term participation in physical activity is crucial for reducing mortality risk.
INTERNATIONAL JOURNAL OF CANCER (2023)
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Article Nutrition & Dietetics
Adherence to cancer prevention recommendations is associated with a lower breast cancer risk in black urban South African women
Inarie Jacobs, Christine Taljaard-Krugell, Mariaan Wicks, Herbert Cubasch, Maureen Joffe, Ria Laubscher, Isabelle Romieu, Carine Biessy, Marc J. Gunter, Inge Huybrechts, Sabina Rinaldi
Summary: The study found that greater adherence to the 2018 WCRF/AICR Cancer Prevention Recommendations was significantly associated with a reduced risk of breast cancer, especially in postmenopausal women and obese women. This suggests that adherence to these recommendations could be an effective strategy for breast cancer prevention in the black urban population of Soweto.
BRITISH JOURNAL OF NUTRITION (2022)
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Article Food Science & Technology
Adolescents' dietary polyphenol intake in relation to serum total antioxidant capacity: the HELENA study
Ratih W. Wisnuwardani, Stefaan De Henauw, Maria Forsner, Frederic Gottrand, Inge Huybrechts, Antonios G. Kafatos, Mathilde Kersting, Viktoria Knaze, Yannis Manios, Esther Nova, Denes Molnar, Joseph A. Rothwell, Augustin Scalbert, Stefania Sette, Kurt Widhalm, Luis A. Moreno, Nathalie Michels
Summary: European adolescents had low dietary polyphenol intake, and there was no linear association between dietary polyphenols and serum total antioxidant capacity. Future studies should use polyphenol biomarkers and additional antioxidant measures to confirm these findings.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2022)
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Review Oncology
Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones
Christopher T. V. Swain, Ann E. Drummond, Leonessa Boing, Roger L. Milne, Dallas R. English, Kristy A. Brown, Eline H. van Roekel, Suzanne C. Dixon-Suen, Michael J. Lynch, Melissa M. Moore, Tom R. Gaunt, Richard M. Martin, Sarah J. Lewis, Brigid M. Lynch
Summary: Physical activity has an effect on sex steroid hormone levels, with a decrease in estrogens, progestins, and androgens, and an increase in sex hormone binding globulin. These findings support the role of physical activity in preventing breast cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2022)
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Article Public, Environmental & Occupational Health
Adherence to the South African food based dietary guidelines may reduce breast cancer risk in black South African women: the South African Breast Cancer (SABC) study
Inarie Jacobs, Christine Taljaard-Krugell, Mariaan Wicks, Jane M. Badham, Herbert Cubasch, Maureen Joffe, Ria Laubscher, Isabelle Romieu, Carine Biessy, Marc J. Gunter, Sabina Rinaldi, Inge Huybrechts
Summary: The study revealed a negative correlation between higher adherence to the South African food based dietary guidelines and breast cancer risk. Only about 30% of cases and controls achieved adherence to at least half of the guidelines.
PUBLIC HEALTH NUTRITION (2022)
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Review Biochemistry & Molecular Biology
Assessment of Fruit and Vegetables Intake with Biomarkers in Children and Adolescents and Their Level of Validation: A Systematic Review
Li Yuan, Samuel Muli, Inge Huybrechts, Ute Noethlings, Wolfgang Ahrens, Augustin Scalbert, Anna Floegel
Summary: There is a lack of research on biomarkers of fruit and vegetable intake in children and adolescents, but potential biomarkers have been identified with distinct characteristics compared to adults. Further studies are needed to validate these biomarkers and apply them in epidemiological studies.
METABOLITES (2022)
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Article Nutrition & Dietetics
Longitudinal associations of fast foods, red and processed meat, alcohol and sugar-sweetened drinks with quality of life and symptoms in colorectal cancer survivors up to 24 months post-treatment
Marlou-Floor Kenkhuis, Floortje Mols, Eline H. H. van Roekel, Jose J. L. Breedveld-Peters, Stephanie Breukink, Maryska Janssen-Heijnen, Eric Keulen, Fraenzel J. van Duijnhoven, Matty P. P. Weijenberg, Martijn Bours
Summary: Unhealthy dietary habits, such as intake of ultra-processed foods, red and processed meat, alcohol, and sugar-sweetened drinks, are longitudinally associated with lower health-related quality of life (HRQoL) and more symptoms in colorectal cancer survivors. However, the association between alcohol intake and improved HRQoL and less fatigue should be interpreted cautiously based on time-lag analysis.
BRITISH JOURNAL OF NUTRITION (2023)
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Article Oncology
Longitudinal associations of plasma metabolites with persistent fatigue among colorectal cancer survivors up to 2 years after treatment
Eline H. van Roekel, Martijn J. L. Bours, Stephanie O. Breukink, Michel Aquarius, Eric T. P. Keulen, Audrey Gicquiau, Sabina Rinaldi, Paolo Vineis, Ilja C. W. Arts, Marc J. Gunter, Michael F. Leitzmann, Augustin Scalbert, Matty P. Weijenberg
Summary: Further investigation is needed to understand the biological mechanisms causing persistent fatigue after colorectal cancer treatment. This study found longitudinal associations between various metabolites and fatigue in colorectal cancer survivors, suggesting inflammation and mitochondrial dysfunction as underlying mechanisms. These findings contribute to a better understanding of persistent fatigue after colorectal cancer treatment.
INTERNATIONAL JOURNAL OF CANCER (2023)
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Article Oncology
Longitudinal associations of sedentary behavior and physical activity with body composition in colorectal cancer survivors up to 2 years post treatment
Marlou-Floor Kenkhuis, Mo Klingestijn, Anne-Marie Fanshawe, Stephanie O. Breukink, Maryska L. G. Janssen-Heijnen, Eric T. P. Keulen, Sabina Rinaldi, Paolo Vineis, Marc J. Gunter, Michael F. Leitzmann, Augustin Scalbert, Matty P. Weijenberg, Martijn J. L. Bours, Eline H. van Roekel
Summary: This study examined the longitudinal associations of sedentary behavior, light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with body composition in colorectal cancer survivors. The results showed that less sedentary time and LPA were associated with increased handgrip strength, independent of MVPA. However, they were not associated with measures of adiposity. On the other hand, more MVPA was associated with increased adiposity and handgrip strength. Additionally, higher BMI partly mediated the associations between higher sedentary time and more fatigue.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2023)
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Review Oncology
Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Christopher T. V. Swain, Ann E. Drummond, Roger L. Milne, Dallas R. English, Kristy A. Brown, Makayla W. C. Lou, Leonessa Boing, Amy Bageley, Tina L. Skinner, Eline H. van Roekel, Melissa M. Moore, Tom R. Gaunt, Richard M. Martin, Sarah J. Lewis, Brigid M. Lynch
Summary: The protective effect of physical activity on breast cancer incidence may be partly mediated by inflammation. Meta-analyses of intervention studies showed that exercise interventions reduced levels of circulating inflammatory biomarkers, providing support for the biological plausibility of the physical activity-inflammation-breast cancer pathway.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2023)
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Review Oncology
Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Makayla W. C. Lou, Ann E. Drummond, Christopher T. V. Swain, Roger L. Milne, Dallas R. English, Kristy A. Brown, Eline H. van Roekel, Tina L. Skinner, Melissa M. Moore, Tom R. Gaunt, Richard M. Martin, Sarah J. Lewis, Brigid M. Lynch
Summary: This review examined the evidence on the connection between inflammation and breast cancer risk. Through systematic searches, prospective cohort studies and Mendelian randomization studies were analyzed. Meta-analysis of 13 inflammation biomarkers suggested that higher levels of C-reactive protein (CRP) were associated with increased breast cancer risk, while higher levels of adiponectin were associated with reduced risk. However, Mendelian randomization analysis did not support the findings for adiponectin. There was limited evidence of the impact of cytokines on breast cancer risk. The quality of evidence ranged from very low to moderate, and beyond CRP, the role of inflammation in breast cancer development is not clear.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2023)
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Article Oncology
Prospective Analysis Reveals Associations between Carbohydrate Intakes, Genetic Predictors of Short-Chain Fatty Acid Synthesis, and Colorectal Cancer Risk
Cody Z. Watling, Rebecca K. Kelly, Neil Murphy, Marc Gunter, Carmen Piernas, Kathryn E. Bradbury, Julie A. Schmidt, Timothy J. Key, Aurora Perez-Cornago
Summary: Higher intakes of whole grains and fiber are associated with lower risk of colorectal cancer, especially in individuals with high production of short-chain fatty acids (SCFA). The study found that consuming more whole grain starch and non-free sugar was inversely associated with colorectal cancer risk. However, this protective effect of whole grain intake may vary depending on an individual's genetic predisposition for SCFA production.
CANCER RESEARCH (2023)
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Article Oncology
Use of menopausal hormone therapy and ovarian cancer risk in a French cohort study
Agnes Fournier, Manon Cairat, Gianluca Severi, Marc J. Gunter, Sabina Rinaldi, Laure Dossus
Summary: Epidemiological studies have found a link between menopausal hormone therapy (MHT) use and increased risk of ovarian cancer, but the impact of different MHT types is unclear. This study examined the associations between different MHT types and ovarian cancer risk in a prospective cohort, finding that different MHT types may impact ovarian cancer risk differently.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2023)
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Article Oncology
Higher Plasma Creatinine Is Associated with an Increased Risk of Death in Patients with Non-Metastatic Rectal but Not Colon Cancer: Results from an International Cohort Consortium
Jennifer Ose, Biljana Gigic, Stefanie Brezina, Tengda Lin, Anita R. Peoples, Pauline P. Schobert, Andreas Baierl, Eline van Roekel, Nivonirina Robinot, Audrey Gicquiau, David Achaintre, Augustin Scalbert, Fraenzel J. B. van Duijnhoven, Andreana N. Holowatyj, Tanja Gumpenberger, Petra Schrotz-King, Alexis B. Ulrich, Arve Ulvik, Per-Magne Ueland, Matty P. Weijenberg, Nina Habermann, Pekka Keski-Rahkonen, Andrea Gsur, Dieuwertje E. Kok, Cornelia M. Ulrich
Summary: Colorectal cancer is recognized as two separate diseases: colon cancer and rectal cancer, each with its own causes and outcomes. This study found that higher levels of plasma creatinine increased the risk of death in patients with rectal cancer but not colon cancer. Additionally, a biological pathway related to starch and sucrose metabolism was linked to worse clinical outcomes in colon cancer but not rectal cancer. Understanding these differences is crucial for tailored treatments.
CANCERS (2023)
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Article Oncology
Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study
Alexi N. Archambault, Jihyoun Jeon, Yi Lin, Minta Thomas, Tabitha A. Harrison, D. Timothy Bishop, Hermann Brenner, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Jane C. Figueiredo, Steven Gallinger, Stephen B. Gruber, Marc J. Gunter, Feng Guo, Michael Hoffmeister, Mark A. Jenkins, Temitope O. Keku, Loic Le Marchand, Li Li, Victor Moreno, Polly A. Newcomb, Rish Pai, Patrick S. Parfrey, Gad Rennert, Lori C. Sakoda, Jeffrey K. Lee, Martha L. Slattery, Mingyang Song, Aung Ko Win, Michael O. Woods, Neil Murphy, Peter T. Campbell, Yu-Ru Su, Iris Lansdorp-Vogelaar, Elisabeth F. P. Peterse, Yin Cao, Anne Zeleniuch-Jacquotte, Peter S. Liang, Mengmeng Du, Douglas A. Corley, Li Hsu, Ulrike Peters, Richard B. Hayes
Summary: This study developed risk prediction models for early-onset colorectal cancer (CRC) that incorporate an environmental risk score (ERS) and a polygenic risk score (PRS). The study found that increasing values of ERS and PRS were associated with increasing relative risks for early-onset CRC. Personal risk scores have the potential to identify individuals at differential relative and absolute risk for early-onset CRC, and may improve screening and outcomes.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2022)
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